Thermoregulation: What Role for UCPs in Mammals and Birds?

  title={Thermoregulation: What Role for UCPs in Mammals
and Birds?},
  author={Julien Mozo and Yalin Emre and Fr{\'e}d{\'e}ric Bouillaud and Daniel Ricquier and François Criscuolo},
  journal={Bioscience Reports},
Mammals and birds are endotherms and respond to cold exposure by the means of regulatory thermogenesis, either shivering or non-shivering. In this latter case, waste of cell energy as heat can be achieved by uncoupling of mitochondrial respiration. Uncoupling proteins, which belong to the mitochondrial carrier family, are able to transport protons and thus may assume a thermogenic function. The mammalian UCP1 physiological function is now well understood and gives to the brown adipose tissue… 
An ancient look at UCP1.
Respiration under Control of Uncoupling Proteins: Clinical Perspective
The main challenge today consists first of all in providing mechanistic explanation for their functions in cellular physiology and this lively awaited information may be the basis for potential pharmacological targeting of the UCPs in future.
In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments
This is the first evidence that the capacity for thermogenesis may be acquired by differentiating adipose tissue into beige-like fat for maintaining temperature homeostasis in the subcutaneous fat ‘neck warmer’ in chickens exposed to a cold environment.
How does mitochondrial function relate to thermogenic capacity and basal metabolic rate in small birds?
Cold acclimation increased overall aerobic capacity of pectoralis muscle and liver respiratory capacity and correlated positively with mitochondrial proton leak in the muscle of cold-acclimated birds while BMR correlated with OXPHOSCI in the liver with a pattern that differed between treatments.
A Novel Role for Arginine in Enhancing Neonatal Thermogenesis
Testing the hypothesis that increased the amount of fetal BAT will enhance neonatal thermogenesis at birth and thus combat the effects of cold stress found that maternal arginine supplementation increased fetal peri-renal BAT by 62%.
Physiological importance and control of non-shivering facultative thermogenesis.
This review examines general and evolutionary aspects of temperature homeostasis, focusing on mammalian facultative or adaptive thermogenesis and its control by the sympathetic nervous system and
Endocrinology of thermoregulation in birds in a changing climate


Adaptive thermogenesis in hummingbirds.
The recent characterization of an uncoupling protein homolog in avian skeletal muscle and the expression of its mRNA at different stages of the torpor/rewarming cycle of hummingbirds indicate that it has the potential to function as an uncOUpling protein and could play a thermogenic role during rewarming in these birds.
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
The role of UCP in the regulation of body mass is determined by targeted inactivation of the gene encoding it by finding that UCP-deficient mice consume less oxygen after treatment with a β3-adrenergic-receptor agonist and are sensitive to cold, indicating that their thermo-regulation is defective.
Facultative and obligatory thermogenesis in young birds: a cautionary note.
  • E. Hohtola
  • Biology
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2002
Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered
The present paper traces first, from a historical perspective, the landmark events in the field of thermogenesis that led to the identification of these genes encoding candidate UCP, and addresses the controversies and on-going debate about their physiological importance in adaptive thermogenesis, in lipid oxidation or in oxidative stress.
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.
A major goal will be to investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body.
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
The discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, is reported, and properties consistent with a role in diabetes and obesity are described, suggesting that U CP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli.
Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance
UCPs are known or supposed to participate in basal and regulatory thermogenesis, but their exact biochemical and physiological functions have yet to be elucidated; very recent data suggest an important role for the UCPs in the control of production of free radicals by mitochondria, and in response to oxidants.
An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds.
The present data support the implication of avUCP in avian energy expenditure and its expression is restricted to skeletal muscle and its abundance was increased 1.3-fold in a chicken line showing diet-induced thermogenesis.