Thermoregulation: What Role for UCPs in Mammals and Birds?

@article{Mozo2005ThermoregulationWR,
  title={Thermoregulation: What Role for UCPs in Mammals
and Birds?},
  author={J. Mozo and Y. Emre and F. Bouillaud and D. Ricquier and F. Criscuolo},
  journal={Bioscience Reports},
  year={2005},
  volume={25},
  pages={227-249}
}
Mammals and birds are endotherms and respond to cold exposure by the means of regulatory thermogenesis, either shivering or non-shivering. In this latter case, waste of cell energy as heat can be achieved by uncoupling of mitochondrial respiration. Uncoupling proteins, which belong to the mitochondrial carrier family, are able to transport protons and thus may assume a thermogenic function. The mammalian UCP1 physiological function is now well understood and gives to the brown adipose tissue… Expand

Paper Mentions

An ancient look at UCP1.
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Comparison studies on the structure-function relationships in UCP1 orthologues from different vertebrates are initiated to elucidate when during vertebrate evolution U CP1 gained the biochemical properties required for nonshivering thermogenesis. Expand
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The main challenge today consists first of all in providing mechanistic explanation for their functions in cellular physiology and this lively awaited information may be the basis for potential pharmacological targeting of the UCPs in future. Expand
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This is the first evidence that the capacity for thermogenesis may be acquired by differentiating adipose tissue into beige-like fat for maintaining temperature homeostasis in the subcutaneous fat ‘neck warmer’ in chickens exposed to a cold environment. Expand
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Physiological importance and control of non-shivering facultative thermogenesis.
  • J. Silva
  • Biology, Medicine
  • Frontiers in bioscience
  • 2011
This review examines general and evolutionary aspects of temperature homeostasis, focusing on mammalian facultative or adaptive thermogenesis and its control by the sympathetic nervous system andExpand
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It is proposed that the greater mitochondrial mass in athletic species, such as birds, is advantageous as it should provide a substantial sink for RS, and that flight driven responses may suppress somatic growth and protect DNA from oxidative damage that would otherwise lead to ageing and non-viral cancers. Expand
Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals.
TLDR
The data demonstrate that novel gene function can evolve without de novo gene duplication event, and indicate that positive Darwinian selection acted on UCP1 contributed to the acquisition of an efficient mechanism for body temperature regulation in primitive eutherians. Expand
Uncoupling protein UCP2: When mitochondrial activity meets immunity
TLDR
A model of how the regulation of nutrient oxidation by UCP2 promotes immune cell activation is presented and is presented as a key protein for oxidation of fatty acids, glutamine and glucose. Expand
Neofunctionalization of the UCP1 mediated the non-shivering thermogenesis in the evolution of small-sized placental mammals.
TLDR
It is hypothesize that the independent positive selection events that occurred in these two lineages resulted in two UCP1-mediated NST approaches, namely the cold acute response in the Glires and the reproduction success enhancement in the Afroinsectivores. Expand
Acute cold-induced thermogenesis in neonatal chicks (Gallus gallus).
  • A. Mujahid
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2010
TLDR
The possible role of HPA-axis in cold-tolerant neonatal chicks to modulate substrate mobilization and oxidation and the thermogenic mechanisms based in part upon the increased capacity for mitochondrial substrate oxidation in different tissues are associated with enhanced heat production to attain homeothermy and acquire tolerance to acute cold exposure during an early stage of Neonatal chicks. Expand
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