Thermoplastic microfluidic platform for single-molecule detection, cell culture, and actuation.

@article{Melin2005ThermoplasticMP,
  title={Thermoplastic microfluidic platform for single-molecule detection, cell culture, and actuation.},
  author={Jonas Melin and Henrik Johansson and Ola S{\"o}derberg and Fredrik Nikolajeff and Ulf Landegren and Mats Nilsson and Jonas Jarvius},
  journal={Analytical chemistry},
  year={2005},
  volume={77 22},
  pages={7122-30}
}
We have developed a multipurpose microfluidic platform that allows for sensitive fluorescence detection on inexpensive disposable chips. The fabrication scheme involves rapid injection molding of thermoplastics, followed by silica deposition and covalent attachment of an unstructured flexible lid. This combines the virtues of elastomer technology with high-throughput compact disk injection molding. Using this technique, the time to produce 100 chips using a single master can be lowered from… CONTINUE READING