Thermophilic prokaryotes have characteristic patterns of codon usage, amino acid composition and nucleotide content.

@article{Singer2003ThermophilicPH,
  title={Thermophilic prokaryotes have characteristic patterns of codon usage, amino acid composition and nucleotide content.},
  author={Gregory A. C. Singer and Donal A. Hickey},
  journal={Gene},
  year={2003},
  volume={317 1-2},
  pages={39-47}
}
A number of recent studies have shown that thermophilic prokaryotes have distinguishable patterns of both synonymous codon usage and amino acid composition, indicating the action of natural selection related to thermophily. On the other hand, several other studies of whole genomes have illustrated that nucleotide bias can have dramatic effects on synonymous codon usage and also on the amino acid composition of the encoded proteins. This raises the possibility that the thermophile-specific… CONTINUE READING
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