Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

@article{Finley1984ThermolabilityOU,
  title={Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85},
  author={Daniel Daniel Finley and Aaron Ciechanover and Alexander Varshavsky},
  journal={Cell},
  year={1984},
  volume={37},
  pages={43-55}
}
Ubiquitin, a 76 residue protein, occurs in eucaryotic cells either free or covalently joined to a variety of protein species. Previous work suggested that ubiquitin may function as a signal for attack by proteinases specific for ubiquitin-protein conjugates. We show that the mouse cell line ts85 , a previously isolated cell cycle mutant, is temperature-sensitive in ubiquitin-protein conjugation, and that this effect is due to the specific thermolability of the ts85 ubiquitin-activating enzyme… CONTINUE READING
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