Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.

@article{Kluijtmans1997ThermolabileMR,
  title={Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.},
  author={L. Kluijtmans and J. Kastelein and J. Lindemans and G. Boers and S. Heil and A. V. Bruschke and J. Jukema and L. van den Heuvel and F. Trijbels and G. Boerma and F. Verheugt and F. Willems and H. Blom},
  journal={Circulation},
  year={1997},
  volume={96 8},
  pages={
          2573-7
        }
}
BACKGROUND Hyperhomocysteinemia, an independent and graded risk factor for coronary artery disease (CAD), may result from both environmental and hereditary factors. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of methylenetetrahydrofolate to methyltetrahydrofolate, the methyl donor in the remethylation of homocysteine to methionine. A 677C-->T mutation in the MTHFR gene has been associated with elevated homocysteine concentrations in homozygous (+/+) individuals… Expand
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Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project.
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