Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis.

@article{Matthias2000ThermogenicRI,
  title={Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis.},
  author={Anita Matthias and Kerstin B E Ohlson and J. Magnus Fredriksson and Anders Jacobsson and Jan Nedergaard and Barbara A Cannon},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 33},
  pages={25073-81}
}
To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was investigated. Ucp1(-/-) cells had a basal metabolic rate identical to wild-type; the mitochondria within them were coupled to the same degree. The response to norepinephrine in wild-type cells was robust ( approximately 10-fold increase in thermogenesis); Ucp1(-/-) cells only responded approximately 3% of this. Ucp1(-/-) cells… CONTINUE READING
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