Thermogenic and metabolic antiobesity drugs: rationale and opportunities

@article{Clapham2007ThermogenicAM,
  title={Thermogenic and metabolic antiobesity drugs: rationale and opportunities},
  author={John C. Clapham and Jonathan Robert Sanders Arch},
  journal={Diabetes},
  year={2007},
  volume={9}
}
Antiobesity drugs that target peripheral metabolism may avoid some of the problems that have been encountered with centrally acting anorectic drugs. Moreover, if they cause weight loss by increasing fat oxidation, they not only address a cause of obesity but also should promote loss of fat rather than lean tissue and improve insulin sensitivity. Weight loss may be slow but more sustained than with anorectic drugs, and thermogenesis may be insufficient to cause any discomfort. Some thermogenic… 

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