Thermogenic and lipolytic effect of yohimbine in the dog.

@article{Galitzky1991ThermogenicAL,
  title={Thermogenic and lipolytic effect of yohimbine in the dog.},
  author={J Galitzky and Michel Vermorel and Max Lafontan and Paul Montastruc and Michel Berlan},
  journal={British journal of pharmacology},
  year={1991},
  volume={104 2},
  pages={
          514-8
        }
}
1. Lipid mobilization during a hypocaloric diet may be enhanced by a pharmacological approach using alpha 2-adrenoceptor antagonists since these drugs are known to increase sympathetic tone and stimulate lipolysis. Studies were undertaken in the dog in order to evaluate the effects of oral yohimbine administration (alpha 2-adrenoceptor antagonist) on heat production, metabolic, endocrinological and cardiovascular parameters. 2. Acute oral yohimbine (0.25 or 0.40 mg kg-1) provoked an increase in… CONTINUE READING

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