Thermogenic activation induces FGF21 expression and release in brown adipose tissue.

@article{Hondares2011ThermogenicAI,
  title={Thermogenic activation induces FGF21 expression and release in brown adipose tissue.},
  author={Elayne Hondares and R Blanco Iglesias and Albert Giralt and Frank J. Gonzalez and Marta Giralt and Teresa Mampel and F Villarroya},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 15},
  pages={12983-90}
}
FGF21 is a novel metabolic regulator involved in the control of glucose homeostasis, insulin sensitivity, and ketogenesis. The liver has been considered the main site of production and release of FGF21 into the blood. Here, we show that, after thermogenic activation, brown adipose tissue becomes a source of systemic FGF21. This is due to a powerful cAMP… CONTINUE READING