Thermogelling bioadhesive scaffolds for intervertebral disk tissue engineering: preliminary in vitro comparison of aldehyde-based versus alginate microparticle-mediated adhesion.

@article{Wiltsey2015ThermogellingBS,
  title={Thermogelling bioadhesive scaffolds for intervertebral disk tissue engineering: preliminary in vitro comparison of aldehyde-based versus alginate microparticle-mediated adhesion.},
  author={Craig Wiltsey and Thomas R Christiani and James Williams and J Scaramazza and C Van Sciver and Katelynn A Toomer and Jason Sheehan and Adriana Branda and Angelika Nitzl and Elizabeth England and Jennifer Kadlowec and Cristina Iftode and Jennifer Vernengo},
  journal={Acta biomaterialia},
  year={2015},
  volume={16},
  pages={71-80}
}
Tissue engineering of certain load-bearing parts of the body can be dependent on scaffold adhesion or integration with the surrounding tissue to prevent dislocation. One such area is the regeneration of the intervertebral disc (IVD). In this work, poly(N-isopropylacrylamide) (PNIPAAm) was grafted with chondroitin sulfate (CS) (PNIPAAm-g-CS) and blended with aldehyde-modified CS to generate an injectable polymer that can form covalent bonds with tissue upon contact. However, the presence of the… CONTINUE READING