Thermodynamics of polyethylenimine-DNA binding and DNA condensation.

  title={Thermodynamics of polyethylenimine-DNA binding and DNA condensation.},
  author={Kuniharu Utsuno and Hasan Uludağ},
  journal={Biophysical journal},
  volume={99 1},
In this study, polyethylenimine (PEI) binding to DNA was examined by isothermal titration calorimetry. Two types of binding modes were found to describe the interactions between these polyelectrolytes in buffers and in water. One type of binding involves PEI binding to the DNA groove because the enthalpy change of this binding mode is positive, and PEI is… CONTINUE READING