Thermodynamics of hydrolysis of peptide bonds.

  title={Thermodynamics of hydrolysis of peptide bonds.},
  author={A. Dobry and J. Fruton and J. Sturtevant},
  journal={The Journal of biological chemistry},
  volume={195 1},
In an accompanying paper, Dobry and Sturtevant (1) have outlined a calorimetric procedure by which the heats of hydrolysis of amides and peptides can be determined. Application of this method to a hydrolysis for which the equilibrium can be determined is of considerable interest, since it then becomes possible to evaluate directly, for the first time, the thermodynamic functions pertinent to such a reaction taking place under conditions not differing significantly from those existing during the… Expand
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ThepH dependence of the equilibrium constantKHyd for the hydrolysis of the Lys15-Ala16 reactive-site peptide bond in bovine pancreatic trypsin inhibitor (aprotinin)
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Possible Role of Proteolytic Enzymes in Protein Synthesis
It is shown beyond doubt that some or perhaps most proteolytic enzymes can catalyse polypeptide synthesis from amino-acids, providing there is an independent method of ‘energizing’ the amino-acid (ester, amide, peptide, etc.). Expand
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A uust 27
  • Proceedings of the 6th International Congress of Experimental Cytology, Stockholm,
  • 1950
Proteins, amino acids and peptides
Proteins, amino acids and peptides, American Chemical Society monograph series
  • New York,
  • 1943