Thermodynamics of binding interactions in the rational drug design process.

Abstract

Modern drug discovery usually involves the rapid screening of large numbers of compounds, either individually or in resolvable mixtures. These compounds may be complex and lead-like or may be small fragments representing optimal scaffolds. Several methods are suitable for detecting binding interactions based on a wide range of different physical platforms… (More)
DOI: 10.1517/17460441.2.8.1103

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