Thermodynamics and Folding Kinetics Analysis of the SH 3 Domain from Discrete Molecular Dynamics

Department of Chemistry and Chemical Biology, Harvard University, Cambridge MA 02138, USA We perform a detailed analysis of the thermodynamics and folding kinetics of the SH3 domain fold with discrete molecular dynamic simulations. We propose a protein model that reproduces some of the experimentally observed thermodynamic and folding kinetic properties of… (More)