Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs.

@article{Xia1998ThermodynamicPF,
  title={Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs.},
  author={Tianbing Xia and J. SantaLucia and Mark E Burkard and Ryszard Kierzek and Susan J Schroeder and Xiaoqi Jiao and Charles Terrence Cox and Douglas H. Turner},
  journal={Biochemistry},
  year={1998},
  volume={37 42},
  pages={
          14719-35
        }
}
Improved thermodynamic parameters for prediction of RNA duplex formation are derived from optical melting studies of 90 oligoribonucleotide duplexes containing only Watson-Crick base pairs. To test end or base composition effects, new sets of duplexes are included that have identical nearest neighbors, but different base compositions and therefore different ends. Duplexes with terminal GC pairs are more stable than duplexes with the same nearest neighbors but terminal AU pairs. Penalizing… CONTINUE READING
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