Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter

Abstract

Peptide transport plays an important role in cellular homeostasis as a key route for nitrogen acquisition in mammalian cells. PepT1 and PepT2, the mammalian proton coupled peptide transporters (POTs), function to assimilate and retain diet-derived peptides and play important roles in drug pharmacokinetics. A key characteristic of the POT family is the… (More)
DOI: 10.7554/eLife.04273

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Cite this paper

@inproceedings{Parker2014ThermodynamicEF, title={Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter}, author={Joanne L. Parker and Joseph A. Mindell and Simon Newstead}, booktitle={eLife}, year={2014} }