Thermodynamic dissociation constants of silychristin, silybin, silydianin and mycophenolate by the regression analysis of spectrophotometric data

@article{Meloun2003ThermodynamicDC,
  title={Thermodynamic dissociation constants of silychristin, silybin, silydianin and mycophenolate by the regression analysis of spectrophotometric data},
  author={Milan Meloun and Dominika Burkoňov{\'a} and Tom{\'a}s Syrov{\'y} and Ale{\vs} Vr{\'a}na},
  journal={Analytica Chimica Acta},
  year={2003},
  volume={486},
  pages={125-141}
}
View via Publisher
40 Citations
Background Citations
5
Methods Citations
2

Figures and Tables from this paper

40 Citations

Citation Type

Citation Type

The thermodynamic dissociation constants of ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine by the regression analysis of spectrophotometric data.
The thermodynamic dissociation constants of haemanthamine, lisuride, metergoline and nicergoline by the regression analysis of spectrophotometric data
The thermodynamic dissociation constants of losartan, paracetamol, phenylephrine and quinine by the regression analysis of spectrophotometric data
The Thermodynamic Dissociation Constants of Azathioprine by the Nonlinear Regression and Factor Analysis of Multiwavelength Spectrophotometric pH-Titration Data
The mixed dissociation constant of azathioprine—chemically 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H- purine at various ionic strengths I of range 0.01-0.2, and at temperatures of 25℃ and 37℃, was…
Thermodynamic protonation constants of vardenafil by the nonlinear regression of multiwavelength pH-spectrophotometric titration data
AbstractpH-spectrophotometric titration data were used to determine protonation constants of vardenafil at different ionic strengths I and temperatures of 25°C and 37°C. The use of two different…
The thermodynamic dissociation constants of methotrexate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data
AbstractThe mixed dissociation constants of methotrexate — chemically (2S)-2-[(4-{[(2,4-diamino-7,8-dihydropteridin-6-yl)methyl] (methyl)amino}phenyl)formamido]pentanedioic acid (the cas number…
Thermodynamic Dissociation Constants of Rasagiline by the Nonlinear Regression and Factor Analysis of Multiwavelength Spectrophotometric pH Titration Data
The mixed dissociation constants of rasagiline-free base [N-propargyl-1-(R)aminoindan] and rasagiline mesylate {[N-propargyl-1-(R)aminoindan]methansulfonate} at different ionic strengths I in the…
The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data.
Recent Progress in the pKa Estimation of Druglike Molecules by the Nonlinear Regression of Multiwavelength Spectrophotometric pH-Titration Data
Recent developments in the computational diagnostic tools for the p K a estimation of druglike molecules carried out by the nonlinear regression of multiwavelength spectrophotometric pH-titration…
The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data.
...
...

References

SHOWING 1-10 OF 56 REFERENCES
Thermodynamic dissociation constants of isocaine, physostigmine and pilocarpine by regression analysis of potentiometric data.
Thermodynamic dissociation constants of codeine, ethylmorphine and homatropine by regression analysis of potentiometric titration data
Silybin, a new iron-chelating agent.
Scavenging of reactive oxygen species by silibinin dihemisuccinate.
Protection by silibinin against Amanita phalloides intoxication in beagles.
Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells.
A computational approach to the spectrophotometric determination of stability constants-II Application to metalloporphyrin-axial ligand interactions in non-aqueous solvents.
Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant.
Effects of Silymarin MZ-80 on Hepatic Oxidative Stress in Rats with Biliary Obstruction
TLDR
All three derivatives of silymarin show a clear ability to reduce lipid peroxidation in the liver in rats with extrahepatic biliary obstruction and sham-operated animals.
Silymarin protects against paracetamol‐induced lipid peroxidation and liver damage
TLDR
It was concluded that silymarin can protect against APAP intoxication through its antioxidant properties, possibly acting as a free‐radical scavenger.
...
...