Thermodynamic characterization of the binding of naphthyridines to the AP site-containing DNA duplexes.

Abstract

We here report on the thermodynamics of the hydrogen bond-mediated binding of 2-amino-7-methyl-1,8-naphthyridine (AMND) to a cytosine base opposite an abasic site (AP site) in a 21-meric DNA duplex (5'-GCA GCT CCC GXG GTC TCC TCG-3'/3'-CGT CGA GGG CCC CAG AGG AGC-5', X= AP site, C = target). The examination by fluorescence titration experiments shows a 1:1… (More)

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@article{Sato2006ThermodynamicCO, title={Thermodynamic characterization of the binding of naphthyridines to the AP site-containing DNA duplexes.}, author={Yusuke Sato and Takehiro Seino and Seiichi Nishizawa and Norio Teramae}, journal={Nucleic acids symposium series}, year={2006}, volume={50}, pages={219-20} }