Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors

@inproceedings{ValleBlislea2009ThermodynamicBF,
  title={Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors},
  author={Alexis Vall{\'e}e-B{\'e}lislea and Francesco Riccia and Kevin W. Plaxcoa},
  year={2009}
}
  • Alexis Vallée-Bélislea, Francesco Riccia, Kevin W. Plaxcoa
  • Published 2009
Binding-induced biomolecular switches are used throughout nature and, increasingly, throughout biotechnology for the detection of chemical moieties and the subsequent transduction of this detection into useful outputs. Here we show that the thermodynamics of these switches are quantitatively described by a simple 3-state population-shift model, in which the equilibrium between a nonbinding, nonsignaling state and the binding-competent, signaling state is shifted toward the latter upon target… CONTINUE READING