Thermodynamic analysis of nylon nucleic acids.


The stability and structure of nylon nucleic acid duplexes with complementary DNA and RNA strands was examined. Thermal denaturing studies of a series of oligonucleotides that contained nylon nucleic acids (1-5 amide linkages) revealed that the amide linkage significantly enhanced the binding affinity of nylon nucleic acids towards both complementary DNA… (More)
DOI: 10.1002/cbic.200800032


Cite this paper

@article{Liu2008ThermodynamicAO, title={Thermodynamic analysis of nylon nucleic acids.}, author={Yu Liu and Risheng Wang and Liang Ding and Ruojie Sha and Philip S. Lukeman and James W. Canary and Nadrian C. Seeman}, journal={Chembiochem : a European journal of chemical biology}, year={2008}, volume={9 10}, pages={1641-8} }