Thermodynamic analysis of calcium and magnesium binding to calmodulin.

  title={Thermodynamic analysis of calcium and magnesium binding to calmodulin.},
  author={Robert Gilli and Daniel Lafitte and Claudia S. L{\'o}pez and M C Kilhoffer and Alexander A. Makarov and Claudette Briand and Jacques Haiech},
  volume={37 16},
To elucidate some aspects still debated concerning the interaction of Ca2+ and Mg2+ with CaM, the thermodynamic binding parameters of Ca2+-CaM and Mg2+-CaM complexes were characterized by flow dialysis and isothermal microcalorimetry under different experimental conditions. In particular, the enthalpy and entropy changes associated with Ca2+ and Mg2+ binding to their sites were determined, allowing a better understanding of the mechanism underlying cation-CaM interactions. Ca2+-CaM interaction… CONTINUE READING

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