Thermodynamic analysis of 5′ and 3′ single- and 3′ double-nucleotide overhangs neighboring wobble terminal base pairs

Abstract

Thermodynamic parameters are reported for duplex formation of 40 self-complementary RNA duplexes containing wobble terminal base pairs with all possible 3' single and double-nucleotide overhangs, mimicking the structures of short interfering RNAs (siRNA) and microRNAs (miRNA). Based on nearest neighbor analysis, the addition of a single 3' dangling… (More)
DOI: 10.1093/nar/gkn525

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@inproceedings{Miller2008ThermodynamicAO, title={Thermodynamic analysis of 5′ and 3′ single- and 3′ double-nucleotide overhangs neighboring wobble terminal base pairs}, author={Stacy Miller and Laura E. Jones and Karen Giovannitti and Dan Piper and Martin J. Serra}, booktitle={Nucleic acids research}, year={2008} }