Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages.

@article{Piperakis2013ThermalSO,
  title={Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages.},
  author={Michael M. Piperakis and J. W. Gaynor and Julie Fisher and Richard Cosstick},
  journal={Organic \& biomolecular chemistry},
  year={2013},
  volume={11 6},
  pages={
          966-74
        }
}
The effect of 3'-S-phosphorothiolate linkages on the stability of RNA·RNA duplexes and G-quadruplex structures has been studied. 3'-Thio-2'-deoxyuridine was incorporated into RNA duplexes and thermal melting studies revealed that the resulting 3'-S-phosphorothiolate linkages increased the stability of the duplex to thermal denaturation. Additionally, and contrary to expectation, a similar effect on duplex stability was observed when the same thionucleoside was incorporated into the RNA strand… 
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