Thermal effects in the organocatalytic asymmetric Mannich reaction.


The proline-catalyzed direct asymmetric Mannich reaction between cyclohexanone, formaldehyde, and various anilines is thermally accelerated. With only 0.5 mol % of catalyst, Mannich products with up to 98% ee have been obtained after a short period of time in reactions performed under microwave irradiation. In situ reduction of the resulting ketones affords N-aryl amino alcohols in up to 86% yield.

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@article{Rodrguez2006ThermalEI, title={Thermal effects in the organocatalytic asymmetric Mannich reaction.}, author={Bel{\'e}n C{\'a}rceles Rodr{\'i}guez and Carsten Bolm}, journal={The Journal of organic chemistry}, year={2006}, volume={71 7}, pages={2888-91} }