Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF--induced thermoablative therapy for human breast cancer in mice.

@article{Denardo2007ThermalDP,
  title={Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF--induced thermoablative therapy for human breast cancer in mice.},
  author={Sally J. Denardo and Gerald L. Denardo and Arutselvan Natarajan and Laird Miers and Allan R Foreman and Cordula Gruettner and Grete N Adamson and Robert Ivkov},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2007},
  volume={48 3},
  pages={437-44}
}
UNLABELLED Antibody (mAb)-linked iron oxide nanoparticles (bioprobes) provide the opportunity to develop tumor specific thermal therapy (Rx) for metastatic cancer when inductively heated by an externally applied alternating magnetic field (AMF). To evaluate the potential of this Rx, in vivo tumor targeting, efficacy, and predictive radionuclide-based heat dosimetry were studied using (111)In-ChL6 bioprobes (ChL6 is chimeric L6) in a human breast cancer xenograft model. METHODS Using… CONTINUE READING

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