Thermal analysis of the crystallization and melting behavior of lipid matrices and lipid nanoparticles containing high amounts of lecithin.

@article{Schubert2005ThermalAO,
  title={Thermal analysis of the crystallization and melting behavior of lipid matrices and lipid nanoparticles containing high amounts of lecithin.},
  author={Martin Alexander Schubert and Bernd Schicke and Christel Charlotte M{\"u}ller-Goymann},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={298 1},
  pages={242-54}
}
Lipid nanoparticles (LNP) based on triglycerides containing high amounts of the amphiphilic lipid lecithin have been proposed as a promising alternative drug delivery system with regard to drug loading capacity. Aim of the present study is to evaluate the influence of lecithin within the lipid matrix (LM) on the crystallization behavior by thermoanalysis and wide angle X-ray diffraction (WAXD). The crystallinity of LM and LNP is mainly determined by the triglyceride content. However, lecithin… CONTINUE READING

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