Thermal Enhancement of New Chemotherapeutic Agents at Moderate Hyperthermia

  title={Thermal Enhancement of New Chemotherapeutic Agents at Moderate Hyperthermia},
  author={MRCS Faheez Mohamed MBChB and Pierre Marchettini and BS O.AnthonyStuart and Muneyasu Urano and FACS FRCS Paul H. Sugarbaker},
  journal={Annals of Surgical Oncology},
Background: Hyperthermia enhances the cytotoxicity of some chemotherapeutic agents. We have studied the effect of moderate hyperthermia (41.5°C) on the cytotoxicity of five new chemotherapeutic agents (docetaxel, paclitaxel, irinotecan, oxaliplatin, and gemcitabine) and melphalan against a spontaneous murine fibrosarcoma. Methods: The tumor was an early-generation isotransplant of a spontaneous C3Hf/Sed mouse fibrosarcoma, FSa-II. Hyperthermia was administered by immersing the tumor-bearing… CONTINUE READING


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