There and back again: The journey of the estrogen-related receptors in the cancer realm

@article{Tam2016ThereAB,
  title={There and back again: The journey of the estrogen-related receptors in the cancer realm},
  author={Ingrid S. Tam and Vincent Gigu{\`e}re},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2016},
  volume={157},
  pages={13-19}
}
The identification of two genes encoding polypeptides with structural features common with the estrogen receptor more than a quarter century ago, referred to as the estrogen-related receptors (ERRs), subsequently led to the discovery of several previously unrecognized hormone responsive systems through the application of reverse endocrinology. Paradoxically, the natural ligand(s) associated with members of the ERR subfamily remains to be identified. While initial studies on the mode of action… CONTINUE READING
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