Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine.

  title={Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine.},
  author={Paulo Ricardo Avancini Caramori and Allan G. Adelman and Eduardo R Azevedo and Gary E. Newton and Anne B Parker and John D Parker},
  journal={Journal of the American College of Cardiology},
  volume={32 7},
OBJECTIVES The purpose of this study was to investigate whether therapy with nitroglycerin (GTN) would lead to abnormal coronary artery responses to the endothelium-dependent vasodilator acetylcholine. BACKGROUND Nitroglycerin therapy is associated with specific biochemical changes in the vasculature that may lead to increased vascular sensitivity to vasoconstrictors. METHODS Patients were randomized to continuous transdermal GTN, 0.6 mg/h (n = 8), or no therapy (n = 7), for 5 days prior to… CONTINUE READING


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