Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties.

@article{Gambero2007TherapyWH,
  title={Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties.},
  author={Sheley Gambero and Andreia Averci Canalli and Fabiola Traina and Dulcineia Martins de Albuquerque and Sara Teresinha Olala Saad and Fernando Ferreira Costa and Nicola Conran},
  journal={European journal of haematology},
  year={2007},
  volume={78 2},
  pages={144-51}
}
Propagation of the vaso-occlusive process in sickle cell anaemia (SCA) is a complex process involving the adhesion of steady-state SCA patients red cells and reticulocytes to the vascular endothelium. The effect of hydroxyurea therapy (HUT) on the adhesive properties of sickle cells and the expression of adhesion molecule genes by erythroid cells of SCA individuals is not yet fully understood. The expressions of the CD36 gene and the VLA-4-integrin subunit genes, CD49d (alpha-subunit) and CD29… CONTINUE READING

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