Therapy response correlates with ALDH activity in ALDH low-positive childhood acute lymphoblastic leukemias.

Abstract

The malignant cells of childhood acute lymphoblastic leukemia (ALL) do not form a homogenous entity but a collection of differently maturated blasts. The most immature leukemia cells may be more resistant to therapy than the bulk of more differentiated blasts. We studied 42 patients with childhood ALL treated according to the ALL-BFM 2000 protocol. At… (More)
DOI: 10.3109/08880018.2013.859189

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