Therapy of tuberculosis in mice by DNA vaccination

@article{Lowrie1999TherapyOT,
  title={Therapy of tuberculosis in mice by DNA vaccination},
  author={Douglas B Lowrie and Ricardo E. Tascon and V{\^a}nia Luiza Deperon Bonato and V M F Lima and L{\'u}cia Helena Faccioli and Evangelos Stavropoulos and Michael Joseph Colston and Robert G. Hewinson and Karin Moelling and C{\'e}lio Lopes Silva},
  journal={Nature},
  year={1999},
  volume={400},
  pages={269-271}
}
Mycobacterium tuberculosis continues to kill about 3 million people every year1, more than any other single infectious agent. This is attributed primarily to an inadequate immune response towards infecting bacteria, which suffer growth inhibition rather than death and subsequently multiply catastrophically. Although the bacillus Calmette–Guérin (BCG) vaccine is widely used, it has major limitations as a preventative measure2. In addition, effective treatment requires that patients take large… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 203 CITATIONS, ESTIMATED 62% COVERAGE

DNA metabolism in mycobacteria

VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Pulmonary necrosis resulting from DNA vaccination against tuberculosis.

  • Infection and immunity
  • 2003
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Influence of a DNA-hsp65 vaccine on bleomycin-induced lung injury.

  • Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • 2008
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The death and resurrection of tuberculosis

  • Nature Medicine
  • 1999
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2018

CITATION STATISTICS

  • 10 Highly Influenced Citations