Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes.

@article{Vaage1993TherapyOM,
  title={Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes.},
  author={Jan Vaage and Duffy Donovan and Eric Mayhew and Paul S. Uster and Martin C. Woodle},
  journal={International journal of cancer},
  year={1993},
  volume={54 6},
  pages={959-64}
}
This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long-circulating liposomes composed of hydrogenated soy-phosphatidylcholine/cholesterol/polyethylene-glycerol-disteroyl++ +- phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over… CONTINUE READING

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This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride , each drug in 2 different formulations : ( i ) as a solution in saline , and ( ii ) encapsulated in sterically stabilized , long - circulating liposomes composed of hydrogenated soy - phosphatidylcholine / cholesterol / polyethylene - glycerol - disteroyl++ + - phosphatidylethanolamine .
This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride , each drug in 2 different formulations : ( i ) as a solution in saline , and ( ii ) encapsulated in sterically stabilized , long - circulating liposomes composed of hydrogenated soy - phosphatidylcholine / cholesterol / polyethylene - glycerol - disteroyl++ + - phosphatidylethanolamine .
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