Therapy of metastatic carcinoid tumor and the malignant carcinoid syndrome with recombinant leukocyte A interferon.

@article{Moertel1989TherapyOM,
  title={Therapy of metastatic carcinoid tumor and the malignant carcinoid syndrome with recombinant leukocyte A interferon.},
  author={Charles G. Moertel and Joseph Rubin and Larry K. Kvols},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1989},
  volume={7 7},
  pages={865-8}
}
Twenty-seven patients with metastatic carcinoid tumor, 24 of whom had the malignant carcinoid syndrome, were treated with recombinant leukocyte A interferon at a planned dose of 24 x 10(6) U/m2. Twenty percent of patients with measurable tumor experienced an objective regression and 39% of those with the carcinoid syndrome experienced a reduction of more than 50% in urine 5-hydroxyindoleacetic acid (5HIAA) excretion. Flushing was partially or completely relieved in 65% of patients and diarrhea… CONTINUE READING

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