Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

Abstract

Intratumoral implantation of murine cells modified to produce retroviral vectors containing the herpes simplex virus-thymidine kinase (HSV-TK) gene induces regression of experimental brain tumors in rodents after ganciclovir (GCV) administration. We evaluated this approach in 15 patients with progressive growth of recurrent malignant brain tumors. Antitumor… (More)
DOI: 10.1038/nm1297-1354

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