Therapy of malignancy-associated hypercalcemia: 1983.

  title={Therapy of malignancy-associated hypercalcemia: 1983.},
  author={Andrew Francis Stewart},
  journal={The American journal of medicine},
  volume={74 3},
Hypercalcemia is common among patients with cancer and may be due to secretion by tumors of a humoral, calcemic, bone-resorbing factor or, alternatively, to skeletal metastases. In each case, hypercalcemia ultimately results from osteoclastic bone resorption. Therapy should be aimed at (1) reducing or eliminating tumor burden, (2) increasing renal calcium clearance, and (3) inhibiting osteoclastic bone resorption. Hydration with saline infusion and augmentation of calciuresis with furosemide… CONTINUE READING