Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone

Abstract

Type I diabetes mellitus is caused by autoimmune destruction of pancreatic beta cells, and effective treatment of the disease might require rescuing beta cell function in a context of reinstalled immune tolerance. Sertoli cells (SCs) are found in the testes, where their main task is to provide local immunological protection and nourishment to developing… (More)
DOI: 10.1084/jem.20090134

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