Therapy of endocrine disease: the challenges in managing giant prolactinomas.

  title={Therapy of endocrine disease: the challenges in managing giant prolactinomas.},
  author={Dominique Maiter and Etienne Delgrange},
  journal={European journal of endocrinology},
  volume={170 6},
Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40  mm or more, significant extrasellar extension, very high PRL concentrations (usually above 1000  μg/l) and no concomitant GH or ACTH secretion. Giant prolactinomas are much more frequent in young… CONTINUE READING
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