Therapy of cytotoxic mushroom intoxication

  title={Therapy of cytotoxic mushroom intoxication},
  author={Sergio Vesconi and Martin Langer and Gaetano Iapichino and D. Costantino and Corrado Busi and Luigi Fiume},
  journal={Critical Care Medicine},
Poisoning by cytotoxic mushrooms (Amanita phalloides and related species) is associated with severe morbidity and a high mortality rate. Due to the difficulty of performing controlled studies and to the poor knowledge of the pharmacodynamics of toxins in human poisoning, there is considerable debate about appropriate treatment, particularly the feasibility and the efficacy of detoxification.Because circulating amatoxins can be detected in the serum of poisoned patients as long as 30 h after… Expand
Acute Liver Failure Caused by Amanita phalloides Poisoning
The pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning, are analyzed. Expand
Plasmapheresis in the treatment of Amanita phalloides poisoning: II. A review and recommendations.
  • S. Jander, J. Bischoff, B. Woodcock
  • Medicine
  • Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
  • 2000
This review of 14 investigations published over the last 20 years shows that the introduction of detoxification techniques, in particular the use of plasmapheresis, in combination with supportive therapy to prevent the absorption of aminitine toxins into blood, produced a substantial reduction in mortality. Expand
Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis
Benzylpenicillin (Penicillin G) alone and in association was the most frequently utilized chemotherapy but showed little efficacy and future clinical research should focus on confirming the efficacy of silybin, N-acetylcysteine, and detoxication procedures. Expand
Amanita poisoning: treatment and the role of liver transplantation.
The pharmacologic basis and clinical manifestations of Amanita intoxication are discussed and the rationale of various treatment modalities are outlined and a protocol that the authors believe will be useful to the clinician is summarized. Expand
Prognosis and treatment options in cases of acute liver failure caused by mushroom poisoning due to Amanita phalloides
Although N-Acetyl Cysteine and Penicillin-G have proven to be effective therapeutic agents, Orthotopic Liver Transplantation (OLT) or Auxiliary Partial Orthotopy Liver Trans transplantation (APOLT is the only treatment option for most of the cases carrying a poor prognosis. Expand
Liver transplantation for severe Amanita phalloides mushroom poisoning.
This largest experience with liver transplantation for Amanita poisoning further defines the early clinical and laboratory indications for, and the unique complicating features of, transplantation in this setting. Expand
Mycotoxins revisited: Part I.
The goal of this two-part article is to review the knowledge base on this subject and provide information that will assist the clinician in the early consideration, diagnosis and treatment of mushroom poisoning. Expand
Cytotoxic fungi--an overview.
Among fungal toxins causing organ damage in the human body, amatoxins and orellanine remain exceptional and the mainstay of treatment is optimum symptomatic and supportive care. Expand
Toxicity and toxicokinetics of Amanita exitialis in beagle dogs
  • Jian Sun, Yu-Min Niu, +8 authors Cheng-ye Sun
  • Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2018
Beagles showed signs of toxicity, such as vomiting and diarrhea, at 12–48 h following ingestion of A. exitialis, and liver histopathological examinations showed hemorrhagic necrosis of hepatocytes, which indicates enhanced excretion of amatoxins in urine could be effective within 2 days after ingestion of a lethal mushroom. Expand
Amanita poisoning during the second trimester of pregnancy
Maternal Amanita poisoning is not necessarily an indication for induced abortion from the second trimester on, as sonographic and obstetric controls failed to show any fetal abnormalities in the acute phase of poisoning. Expand