Therapy of cytotoxic mushroom intoxication

  title={Therapy of cytotoxic mushroom intoxication},
  author={SERGIO VESCONI and Martin Langer and GAETANO IAPICHINO and Domenico Costantino and CARLO BUSI and LUIGI FIUME},
  journal={Critical Care Medicine},
  • Published 1 May 1985
  • Medicine, Biology
  • Critical Care Medicine
Poisoning by cytotoxic mushrooms (Amanita phalloides and related species) is associated with severe morbidity and a high mortality rate. Due to the difficulty of performing controlled studies and to the poor knowledge of the pharmacodynamics of toxins in human poisoning, there is considerable debate about appropriate treatment, particularly the feasibility and the efficacy of detoxification.Because circulating amatoxins can be detected in the serum of poisoned patients as long as 30 h after… 

Acute Liver Failure Caused by Amanita phalloides Poisoning

The pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning, are analyzed.

Plasmapheresis in the treatment of Amanita phalloides poisoning: II. A review and recommendations.

  • S. JanderJ. BischoffB. Woodcock
  • Medicine
    Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
  • 2000
This review of 14 investigations published over the last 20 years shows that the introduction of detoxification techniques, in particular the use of plasmapheresis, in combination with supportive therapy to prevent the absorption of aminitine toxins into blood, produced a substantial reduction in mortality.

Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis

Benzylpenicillin (Penicillin G) alone and in association was the most frequently utilized chemotherapy but showed little efficacy and future clinical research should focus on confirming the efficacy of silybin, N-acetylcysteine, and detoxication procedures.

Mycotoxins revisited: Part I.

Cytotoxic fungi--an overview.

Toxicity and toxicokinetics of Amanita exitialis in beagle dogs

  • Jian SunYu-Min Niu Cheng-ye Sun
  • Medicine, Biology
    Toxicon : official journal of the International Society on Toxinology
  • 2018

Amanita poisoning during the second trimester of pregnancy

Maternal Amanita poisoning is not necessarily an indication for induced abortion from the second trimester on, as sonographic and obstetric controls failed to show any fetal abnormalities in the acute phase of poisoning.

 Early initiation of MARS® dialysis in Amanita phalloides-induced acute liver injury prevents liver transplantation.

ECAD is highly effective in treating intoxication with Amanita phalloides, and early initiation and repeated sessions depending on response to ECAD are suggested with the chance of avoiding liver transplantation.