Therapy of cervical cancer using 131I-labeled nanoparticles

  title={Therapy of cervical cancer using 131I-labeled nanoparticles},
  author={Wei Li and Danyang Sun and Ning Li and Yiming Shen and Yiming Hu and Jian Tan},
  journal={The Journal of International Medical Research},
  pages={2359 - 2370}
  • Wei LiDanyang Sun Jian Tan
  • Published 16 April 2018
  • Biology, Medicine, Chemistry
  • The Journal of International Medical Research
Objective To evaluate the effectiveness of two kinds of Arg-Gly-Asp (RGD)-targeted 131I-containing nanoliposomes for the treatment of cervical cancer in vitro and in vivo. Methods The nanoparticle liposomes designated RGD-131I-tyrosine peptide chain (TPC)-L and 131I-RGD-L were prepared. The emulsion solvent evaporation method was used to encapsulate the polypeptide into liposomes. The quantity of entrapped polypeptide was measured using UV spectrophotometry. The labeling rates, radiochemical… 

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