Therapy of Primary Sclerosing Cholangitis--Today and Tomorrow.

  title={Therapy of Primary Sclerosing Cholangitis--Today and Tomorrow.},
  author={Emina Halilbasic and Claudia Fuchs and Harald Hofer and Gustav Paumgartner and Michael Trauner},
  journal={Digestive diseases},
  volume={33 Suppl 2},
Primary sclerosing cholangitis (PSC) represents a fibro-obliterative bile duct disease with unpredictable individual clinical course that may progress to liver cirrhosis and malignancy. Due to our incomplete understanding of the etiology and pathogenesis of this disease, the therapeutic options are still rather limited. Bile acids play a key role in mediating cholangiocellular and hepatocellular injury in cholangiopathies such as PSC. Therefore, strategies targeting bile composition and… CONTINUE READING
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