Therapy of Infantile Spasms with Valproate: Results of a Prospective Study

@article{Siemes1988TherapyOI,
  title={Therapy of Infantile Spasms with Valproate: Results of a Prospective Study},
  author={H. Siemes and H. Spohr and T. Michael and H. Nau},
  journal={Epilepsia},
  year={1988},
  volume={29}
}
  • H. Siemes, H. Spohr, +1 author H. Nau
  • Published 1988
  • Medicine
  • Epilepsia
  • Summary: In a prospective study, 22 children with recently manifested infantile spasms (18 patients with symptomatic and 4 with idiopathic infantile spasms) were treated with sodium valproate (VPA). Before VPA was instituted, a loading test was performed to exclude abnormal patterns of VPA metabolites by gas chromatography and mass spectroscopy of serum and urrne. This test was repeated during VPA therapy; an abnormal pattern of VPA metabolites was not observed. VPA was started in increasing… CONTINUE READING
    108 Citations
    Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
    • 13
    • PDF
    West Syndrome: Response to Valproate
    • 12
    • Highly Influenced
    • PDF
    Current and future treatment of infantile spasms
    Medical Treatment of Patients With Infantile Spasms
    • 48
    Treatment of infantile spasms: an evidence-based approach.
    • 40

    References

    SHOWING 1-10 OF 21 REFERENCES
    ACTH therapy in infantile spasms: side effects.
    • 190
    • PDF
    Use of valproic acid in treatment of infantile spasms.
    • 79
    Treatment of Infantile Spasms with Sodium Dipropylacetic Acid
    • 47
    Adverse Effects of Valproate
    • 89
    Glucocorticoids are modulators of GABAA receptors in brain
    • 192
    Epilepsy in Children (International Review of Child Neurology Series)
    • 26
    • Highly Influential