Therapy of Infantile Spasms with Valproate: Results of a Prospective Study

  title={Therapy of Infantile Spasms with Valproate: Results of a Prospective Study},
  author={H. Siemes and H. Spohr and T. Michael and H. Nau},
  • H. Siemes, H. Spohr, +1 author H. Nau
  • Published 1988
  • Medicine
  • Epilepsia
  • Summary: In a prospective study, 22 children with recently manifested infantile spasms (18 patients with symptomatic and 4 with idiopathic infantile spasms) were treated with sodium valproate (VPA). Before VPA was instituted, a loading test was performed to exclude abnormal patterns of VPA metabolites by gas chromatography and mass spectroscopy of serum and urrne. This test was repeated during VPA therapy; an abnormal pattern of VPA metabolites was not observed. VPA was started in increasing… CONTINUE READING
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