Therapy of Infantile Spasms with Valproate: Results of a Prospective Study

@article{Siemes1988TherapyOI,
  title={Therapy of Infantile Spasms with Valproate: Results of a Prospective Study},
  author={Hartmut Siemes and H L Spohr and Theodor Michael and Heinz Nau},
  journal={Epilepsia},
  year={1988},
  volume={29}
}
Summary: In a prospective study, 22 children with recently manifested infantile spasms (18 patients with symptomatic and 4 with idiopathic infantile spasms) were treated with sodium valproate (VPA). Before VPA was instituted, a loading test was performed to exclude abnormal patterns of VPA metabolites by gas chromatography and mass spectroscopy of serum and urrne. This test was repeated during VPA therapy; an abnormal pattern of VPA metabolites was not observed. VPA was started in increasing… 
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