Therapy for fibrotic diseases: nearing the starting line.

  title={Therapy for fibrotic diseases: nearing the starting line.},
  author={Scott L Friedman and Dean Sheppard and Jeremy S. Duffield and Shelia M. Violette},
  journal={Science translational medicine},
  volume={5 167},
Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic cirrhosis are among the more common fibrotic diseases, which in aggregate represent a huge unmet clinical need. New appreciation of the common features of fibrosis that are conserved among tissues has led to a clearer understanding of how epithelial injury provokes dysregulation of cell differentiation, signaling… CONTINUE READING


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