Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in Children

@article{Canani2006TherapyWG,
  title={Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in Children},
  author={R. B. Canani and P. Cirillo and P. Roggero and C. Romano and B. Malamisura and G. Terrin and A. Passariello and F. Manguso and L. Morelli and A. Guarino},
  journal={Pediatrics},
  year={2006},
  volume={117},
  pages={e817 - e820}
}
  • R. B. Canani, P. Cirillo, +7 authors A. Guarino
  • Published 2006
  • Medicine
  • Pediatrics
  • OBJECTIVE. Gastric acidity (GA) inhibitors, including histamine-2 receptor antagonists (H2 blockers) and proton pump inhibitors (PPIs), are the mainstay of gastroesophageal reflux disease (GERD) treatment. A prolonged GA inhibitor–induced hypochlorhydria has been suggested as a risk factor for severe gastrointestinal infections. In addition, a number of papers and a meta-analysis have shown an increased risk of pneumonia in H2-blocker–treated intensive care patients. More recently, an increased… CONTINUE READING
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