Therapy Insight: potential of statins for cancer chemoprevention and therapy

@article{Katz2005TherapyIP,
  title={Therapy Insight: potential of statins for cancer chemoprevention and therapy},
  author={M. Katz},
  journal={Nature Clinical Practice Oncology},
  year={2005},
  volume={2},
  pages={82-89}
}
  • M. Katz
  • Published 2005
  • Medicine
  • Nature Clinical Practice Oncology
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, also known as statins, are commonly prescribed medications that lower serum cholesterol and decrease cardiac morbidity and mortality. These agents inhibit the rate-limiting step of the mevalonate pathway, an effect that influences cholesterol homeostasis and other diverse cellular functions. Preclinical data suggest statins have pleiotropic antineoplastic effects in a variety of tumors, but clinical studies have provided… Expand
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