Therapy Insight: parenteral estrogen treatment for prostate cancer—a new dawn for an old therapy

@article{Ockrim2006TherapyIP,
  title={Therapy Insight: parenteral estrogen treatment for prostate cancer—a new dawn for an old therapy},
  author={Jeremy L. Ockrim and El-Nasir Lalani and Paul D. Abel},
  journal={Nature Clinical Practice Oncology},
  year={2006},
  volume={3},
  pages={552-563}
}
Oral estrogens were the treatment of choice for carcinoma of the prostate for over four decades, but were abandoned because of an excess of cardiovascular and thromboembolic toxicity. It is now recognized that most of this toxicity is related to the first pass portal circulation, which upregulates the hepatic metabolism of hormones, lipids and coagulation proteins. Most of this toxicity can be avoided by parenteral (intramuscular or transdermal) estrogen administration, which avoids hepatic… 

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Estrogen and prostate cancer: An eclipsed truth in an androgen‐dominated scenario

  • G. Carruba
  • Biology, Medicine
    Journal of cellular biochemistry
  • 2007
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Secondary hormonal manipulation.

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