Therapy Insight: parenteral estrogen treatment for prostate cancer—a new dawn for an old therapy

@article{Ockrim2006TherapyIP,
  title={Therapy Insight: parenteral estrogen treatment for prostate cancer—a new dawn for an old therapy},
  author={J. Ockrim and E. Lalani and P. Abel},
  journal={Nature Clinical Practice Oncology},
  year={2006},
  volume={3},
  pages={552-563}
}
Oral estrogens were the treatment of choice for carcinoma of the prostate for over four decades, but were abandoned because of an excess of cardiovascular and thromboembolic toxicity. It is now recognized that most of this toxicity is related to the first pass portal circulation, which upregulates the hepatic metabolism of hormones, lipids and coagulation proteins. Most of this toxicity can be avoided by parenteral (intramuscular or transdermal) estrogen administration, which avoids hepatic… Expand
An Update on Triptorelin: Current Thinking on Androgen Deprivation Therapy for Prostate Cancer
Estrogen and prostate cancer: An eclipsed truth in an androgen‐dominated scenario
  • G. Carruba
  • Biology, Medicine
  • Journal of cellular biochemistry
  • 2007
Role of Hormonal Manipulation in Prostate Cancer Management
The effect of estrogen on the sexual interest of castrated males: Implications to prostate cancer patients on androgen-deprivation therapy.
Secondary hormonal manipulation.
Estrogens and prostate cancer
...
1
2
3
4
...

References

SHOWING 1-10 OF 80 REFERENCES
Transdermal estradiol therapy for advanced prostate cancer--forward to the past?
Estrogens in the treatment of prostate cancer.
Cost-effectiveness of androgen suppression therapies in advanced prostate cancer.
...
1
2
3
4
5
...