Therapy: Expanding the horizons of PARP inhibitors

@article{Villanueva2010TherapyET,
  title={Therapy: Expanding the horizons of PARP inhibitors},
  author={Teresa Hern{\'a}ndez Villanueva},
  journal={Nature Reviews Cancer},
  year={2010},
  volume={10},
  pages={814-814}
}
results in hypoxic tumour regions that are distant from blood vessels, as oxygen is poorly delivered to these areas. As drugs are also not efficiently delivered in these circumstances, intratumoral hypoxia is associated with treatment resistance. Rob Bristow and Ester Hammond have come up with a possible solution to selectively target resistant hypoxic tumour cells. It is known that the ability to repair DNA damage by the homologous recombination pathway is impaired in hypoxic cells and that… CONTINUE READING