Therapy: Cell-type-specific approach to TNF inhibition

Abstract

Macrophage TNF TNF inhibitors have proved highly successful in the treatment of numerous autoimmune diseases, but global inhibition of this pleiotropic cytokine may also nullify its protective functions. Emerging evidence that pathogenic TNF is derived from specific cell types in several disease models suggests a novel approach to anti-cytokine therapy that… (More)
DOI: 10.1038/nrrheum.2016.38

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