Therapeutics Targeting Mutant KRAS.

@article{Thein2020TherapeuticsTM,
  title={Therapeutics Targeting Mutant KRAS.},
  author={Kyaw Zin Thein and Amadeo B Biter and David S. Hong},
  journal={Annual review of medicine},
  year={2020}
}
Aberrations in rat sarcoma (RAS) viral oncogene are the most prevalent and best-known genetic alterations identified in human cancers. Indeed, RAS drives tumorigenesis as one of the downstream effectors of EGFR activation, regulating cellular switches and functions and triggering intracellular signaling cascades such as the MAPK, and PI3K pathways. Of the three RAS isoforms expressed in human cells, all of which were linked to tumorigenesis more than three decades ago, KRAS is the most… 

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